TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …

Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

Aberrant expression of microRNAs (miRNAs) and the enzymes that control their processing
have been reported in multiple biological processes including primary and metastatic …

p73 and p63 are two homologs of the tumor suppressive transcription factor p53. Given the
high degree of structural similarity shared by the p53 family members, p73 and p63 can bind …

Introduction Radiotherapy is a mainstay of cancer treatment. Clinical studies revealed a
heterogenous response to radiotherapy, from a complete response to even disease …

The tumor suppressor p53 is a central hub in a molecular network controlling cell
proliferation and death in response to potentially oncogenic conditions, and a wide array of …

The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …

Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators
of ovarian function including the formation of the germ cell precursors, termed primordial …

Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear
envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery …