Simple Summary Glioblastoma is among the most lethal cancers in humans. Glioblastomas
exhibit a striking heterogeneity, which is maintained by a highly plastic, adaptable …

The reversible and precise temporal and spatial regulation of histone lysine
methyltransferases (KMTs) is essential for epigenome homeostasis. The dysregulation of …

Glioblastoma (GBM) is an invasive cancer with high mortality in central nervous system.
Resistance to temozolomide (TMZ) and immunosuppressive microenvironment lead to low …

Simple Summary The large amount of knowledge regarding epigenetic pathways has
opened a broad range of treatments that provide hope for adult patients with highly …

Brain tumors are responsible for high mortality and morbidity worldwide. The brain tumor
treatment depends on identification of molecular pathways involved in progression and …

Temozolomide (TMZ) is the mainstream chemotherapeutic drug for treating glioblastoma
multiforme (GBM), but the intrinsic or acquired chemoresistance to TMZ has become the …

Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of
gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic …

Background The mechanism of recurrence and metastasis of hepatocellular carcinoma
(HCC) is complex and challenging. Methyl-CpG binding domain protein 3 (MBD3) is a key …

Invasive growth of glioblastoma makes residual tumor unremovable by surgery and leads to
disease relapse. Temozolomide is widely used first-line chemotherapy drug to treat glioma …

Background RBBP4 activates transcription by histone acetylation, but the partner histone
acetyltransferases are unknown. Thus, we investigated the hypothesis that RBBP4 interacts …