The biphasic role of Hspb1 on ferroptotic cell death in Parkinson's disease

J Meng, J Fang, Y Bao, H Chen, X Hu, Z Wang… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Ferroptosis-driven loss of dopaminergic neurons plays a pivotal role in the
pathogenesis of Parkinson's disease (PD). In PD patients, Hspb1 is commonly observed at …

Ferroptosis as a promising targeted therapy for triple negative breast cancer

K Mokhtarpour, S Razi, N Rezaei - Breast Cancer Research and …, 2024 - Springer
Purpose Triple negative breast cancer (TNBC) is a challenging subtype characterized by the
absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal …

Modulatory role of prolactin in type 1 diabetes

E Ramos-Martínez, I Ramos-Martínez… - … Molecular Biology and …, 2023 - degruyter.com
Objectives Patients with type 1 diabetes mellitus have been reported to have elevated
prolactin levels and a possible relationship between prolactin levels and the development of …

Integrative analysis of TBI data reveals Lgmn as a key player in immune cell-mediated ferroptosis

L Yan, X Han, M Zhang, Y Fu, F Yang, Q Li, T Cheng - BMC genomics, 2023 - Springer
Background Traumatic brain injury (TBI) is a central nervous system disease caused by
external trauma, which has complex pathological and physiological mechanisms. The aim of …

A Charcot-Marie-Tooth-Causing Mutation in HSPB1 Decreases Cell Adaptation to Repeated Stress by Disrupting Autophagic Clearance of Misfolded Proteins

X Zhang, Y Qiao, R Han, Y Gao, X Yang, Y Zhang… - Cells, 2022 - mdpi.com
Charcot-Marie-Tooth (CMT) disease is the most common inherited neurodegenerative
disorder with selective degeneration of peripheral nerves. Despite advances in identifying …

m6A‐activated BACH1 exacerbates ferroptosis by epigenetic suppression HSPB1 in severe acute pancreatitis

F Zhou, D Li, C Liu, C Li, K Li, L Shi… - Drug Development …, 2024 - Wiley Online Library
Severe acute pancreatitis (SAP) is characterized by acute inflammation of the pancreas. The
transcription factor BTB and CNC homology 1 (BACH1) has been implicated in various …

Biomedical importance of the ubiquitin–proteasome system in diabetes and metabolic transdifferentiation of pancreatic duct epithelial cells into β-cells

Z Liu, P Wang, Y Zhao, KP Lai, R Li - Gene, 2023 - Elsevier
The ubiquitin–proteasome system (UPS) is a major pathway for cellular protein degradation.
The molecular function of the UPS is the removal of damaged proteins, and this function is …

Degradation meets development: Implications in β‐cell development and diabetes

A Ashok, G Kalthur, A Kumar - Cell Biology International, 2024 - Wiley Online Library
Pancreatic development is orchestrated by timely synthesis and degradation of stage‐
specific transcription factors (TFs). The transition from one stage to another stage is …