The signal pathways and treatment of cytokine storm in COVID-19
L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …
and is more devastating than any other previous infectious disease. It has affected a …
Colchicine—update on mechanisms of action and therapeutic uses
Objectives To review the literature and provide an update on the mechanisms of action and
therapeutic uses of oral colchicine in arthritis and inflammatory conditions. Methods We …
therapeutic uses of oral colchicine in arthritis and inflammatory conditions. Methods We …
Effect of colchicine vs standard care on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019: the …
Importance Severe acute respiratory syndrome coronavirus 2 infection has evolved into a
global pandemic. Low-dose colchicine combines anti-inflammatory action with a favorable …
global pandemic. Low-dose colchicine combines anti-inflammatory action with a favorable …
The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation
Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently,
compelling evidence has arisen for the role of monocytes and neutrophils and a particular …
compelling evidence has arisen for the role of monocytes and neutrophils and a particular …
P2X7 receptor and the NLRP3 inflammasome: Partners in crime
P Pelegrin - Biochemical pharmacology, 2021 - Elsevier
Adenosine triphosphate (ATP) is a molecule that on one hand plays a central role in cellular
energetics and which on the other is a ubiquitous signaling molecule when released into the …
energetics and which on the other is a ubiquitous signaling molecule when released into the …
[HTML][HTML] The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design
Objective Colchicine has been utilized safely in a variety of cardiovascular clinical
conditions. Among its potential mechanisms of action is the non-selective inhibition of …
conditions. Among its potential mechanisms of action is the non-selective inhibition of …
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
P2X7 receptor: an emerging target in central nervous system diseases
B Sperlágh, P Illes - Trends in pharmacological sciences, 2014 - cell.com
The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a
potential drug target because of its widespread involvement in inflammatory diseases as a …
potential drug target because of its widespread involvement in inflammatory diseases as a …
Colchicine: an ancient drug with novel applications
B Dasgeb, D Kornreich, K McGuinn… - British Journal of …, 2018 - academic.oup.com
Colchicine is a treatment for gout that has been used for more than a millennium. It is the
treatment of choice for familial Mediterranean fever and its associated complication …
treatment of choice for familial Mediterranean fever and its associated complication …
Inflammation-induced thrombosis: mechanisms, disease associations and management
Although inflammation-induced thrombosis is a well-known entity, its pathogenesis remains
complicated. There are complex interactions between inflammation and hemostasis …
complicated. There are complex interactions between inflammation and hemostasis …