ALS genetics: gains, losses, and implications for future therapies
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …
Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis
Breakthrough discoveries identifying common genetic causes for amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these …
sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these …
Pharmacotherapy for amyotrophic lateral sclerosis: a review of approved and upcoming agents
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …
Protein aggregation in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have …
aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have …
Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease
C Pottier, KF Bieniek, NC Finch, M van de Vorst… - Acta …, 2015 - Springer
Frontotemporal lobar degeneration with TAR DNA-binding protein 43 inclusions (FTLD-
TDP) is the most common pathology associated with frontotemporal dementia (FTD). Repeat …
TDP) is the most common pathology associated with frontotemporal dementia (FTD). Repeat …
Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates
J Korac, V Schaeffer, I Kovacevic… - Journal of cell …, 2013 - journals.biologists.com
Aggregation of misfolded proteins and the associated loss of neurons are considered a
hallmark of numerous neurodegenerative diseases. Optineurin is present in protein …
hallmark of numerous neurodegenerative diseases. Optineurin is present in protein …
ALS: A bucket of genes, environment, metabolism and unknown ingredients
M Zufiria, FJ Gil-Bea, R Fernandez-Torron… - Progress in …, 2016 - Elsevier
The scientific scenario of amyotrophic lateral sclerosis (ALS) has dramatically changed
since TDP-43 aggregates were discovered in 2006 as the main component of the neuronal …
since TDP-43 aggregates were discovered in 2006 as the main component of the neuronal …
Amyotrophic lateral sclerosis: a neurodegenerative motor neuron disease with ocular involvement
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes
degeneration of the lower and upper motor neurons and is the most prevalent motor neuron …
degeneration of the lower and upper motor neurons and is the most prevalent motor neuron …
Misregulated RNA processing in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) research is undergoing an era of unprecedented
discoveries with the identification of new genes as major genetic causes of this disease …
discoveries with the identification of new genes as major genetic causes of this disease …
Dysfunction of optineurin in amyotrophic lateral sclerosis and glaucoma
RP Toth, JD Atkin - Frontiers in immunology, 2018 - frontiersin.org
Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal
dementia, and glaucoma, affect millions of people worldwide. ALS is caused by the loss of …
dementia, and glaucoma, affect millions of people worldwide. ALS is caused by the loss of …