Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

Post-translational modification (PTM) of proteins is vital for increasing proteome diversity
and maintaining cellular homeostasis. If the writing, reading, and removal of modifications …

CARM1 is amplified or overexpressed in many cancer types, and its overexpression
correlates with poor prognosis. Potent small-molecule inhibitors for CARM1 have been …

The coactivator associated arginine methyltransferase (CARM1) promotes transcription, as
its name implies. It does so by modifying histones and chromatin bound proteins. We …

Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a
coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins …

Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

DNA replication forks use multiple mechanisms to deal with replication stress, but how the
choice of mechanisms is made is still poorly understood. Here, we show that CARM1 …