The specific regulation of inflammatory processes by steroid hormones has been actively
studied in recent years, especially by progesterone (P4) and progestins. The mechanisms of …

CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon
tumor antigen stimulation, and then differentiate into functional cells and migrate towards the …

Metabolic reprogramming is a hallmark of activated T cells. The switch from oxidative
phosphorylation to aerobic glycolysis provides energy and intermediary metabolites for the …

Astrocytes contribute to brain inflammation in neurological disorders but the molecular
mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory …

Altered microenvironmental stiffness is a hallmark of inflammation. It is sensed by the
mechanically activated cation channel Piezo1 in macrophages to induce subsequent …

This Review explores the interplay between T cell activation and cell metabolism and
highlights how metabolites serve two pivotal functions in shaping the immune response …

Ions are the cornerstones of various biological functions and have been widely used for
tumor therapy, called ion interference therapy (IIT). Calcium ion (Ca 2+) is one of the most …

The transient receptor potential melastatin subfamily member 2 (TRPM2), a thermo and
reactive oxygen species (ROS) sensitive Ca2+-permeable cation channel has a vital role in …

Upon antigen-specific T cell receptor (TCR) engagement, human CD4+ T cells proliferate
and differentiate, a process associated with rapid transcriptional changes and metabolic …

Over recent years, our understanding of the tricarboxylic acid cycle (TCAC) in living
organisms has expanded beyond its canonical role in cellular energy production. In plants …