Epigenetics of colorectal cancer: biomarker and therapeutic potential

G Jung, E Hernández-Illán, L Moreira… - Nature reviews …, 2020 - nature.com
Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

Cancer biomarkers and their biosensors: A comprehensive review

H Khan, MR Shah, J Barek, MI Malik - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
The article starts with a brief history of discovery of cancer biomarkers followed by statistical
data on published cancer biomarkers detection strategies in the last decade to demonstrate …

The miR-200 family of microRNAs: fine tuners of epithelial-mesenchymal transition and circulating cancer biomarkers

I Cavallari, F Ciccarese, E Sharova, L Urso… - Cancers, 2021 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are small RNA molecules that regulate gene
expression by blocking translation or inducing degradation of specific gene transcripts. The …

Epigenetic alterations in colorectal cancer: emerging biomarkers

Y Okugawa, WM Grady, A Goel - Gastroenterology, 2015 - Elsevier
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers

R Hamam, D Hamam, KA Alsaleh, M Kassem… - Cell death & …, 2017 - nature.com
Effective management of breast cancer depends on early diagnosis and proper monitoring
of patients' response to therapy. However, these goals are difficult to achieve because of the …

[HTML][HTML] Circulating biomarkers for early detection and clinical management of colorectal cancer

M Marcuello, V Vymetalkova, RPL Neves… - Molecular Aspects of …, 2019 - Elsevier
New non-invasive approaches that can complement and improve on current strategies for
colorectal cancer (CRC) screening and management are urgently needed. A growing …

Clinical relevance of circulating cell-free microRNAs in cancer

H Schwarzenbach, N Nishida, GA Calin… - Nature reviews Clinical …, 2014 - nature.com
Efficient patient management relies on early diagnosis of disease and monitoring of
treatment. In this regard, much effort has been made to find informative, blood-based …

Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs

L Min, S Zhu, L Chen, X Liu, R Wei, L Zhao… - Journal of …, 2019 - Taylor & Francis
Early diagnosis of colon cancer (CC) is clinically important, as it can significantly improve
patients' survival rate and quality of life. Although the potential role for small extracellular …

Circulating exosomal microRNAs as biomarkers of colon cancer

H Ogata-Kawata, M Izumiya, D Kurioka, Y Honma… - PloS one, 2014 - journals.plos.org
Purpose Exosomal microRNAs (miRNAs) have been attracting major interest as potential
diagnostic biomarkers of cancer. The aim of this study was to characterize the miRNA …

MicroRNA: function, detection, and bioanalysis

H Dong, J Lei, L Ding, Y Wen, H Ju, X Zhang - Chemical reviews, 2013 - ACS Publications
Mature microRNAs (miRNAs) are a class of evolutionally conserved, single-stranded, small
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …