Cerebellar long-term depression: characterization, signal transduction, and functional roles
M Ito - Physiological reviews, 2001 - journals.physiology.org
Cerebellar Purkinje cells exhibit a unique type of synaptic plasticity, namely, long-term
depression (LTD). When two inputs to a Purkinje cell, one from a climbing fiber and the other …
depression (LTD). When two inputs to a Purkinje cell, one from a climbing fiber and the other …
[HTML][HTML] The optokinetic reflex as a tool for quantitative analyses of nervous system function in mice: application to genetic and drug-induced variation
H Cahill, J Nathans - PloS one, 2008 - journals.plos.org
The optokinetic reflex (OKR), which serves to stabilize a moving image on the retina, is a
behavioral response that has many favorable attributes as a test of CNS function. The OKR …
behavioral response that has many favorable attributes as a test of CNS function. The OKR …
Cerebellar LTD facilitates but is not essential for long‐term adaptation of the vestibulo‐ocular reflex
AM Van Alphen, CI De Zeeuw - European Journal of …, 2002 - Wiley Online Library
The induction of cerebellar long‐term depression (LTD) at the parallel fibre–Purkinje cell
synapse is selectively blocked in L7‐PKCi transgenic mice, rendering these mice unable to …
synapse is selectively blocked in L7‐PKCi transgenic mice, rendering these mice unable to …
Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning
T Sano, A Kohyama-Koganeya, MO Kinoshita… - Neuroscience …, 2018 - Elsevier
GPRC5B is a membrane glycoprotein robustly expressed in mouse cerebellar Purkinje cells
(PCs). Its function is unknown. In Gprc5b−/− mice that lack GPRC5B, PCs develop distal …
(PCs). Its function is unknown. In Gprc5b−/− mice that lack GPRC5B, PCs develop distal …
[HTML][HTML] A quantitative survey of gravity receptor function in mutant mouse strains
SM Jones, KR Johnson, H Yu, LC Erway… - Journal of the …, 2005 - Springer
The purpose of this research was to identify vestibular deficits in mice using linear vestibular
evoked potentials (VsEPs). VsEP thresholds, peak latencies, and peak amplitudes from 24 …
evoked potentials (VsEPs). VsEP thresholds, peak latencies, and peak amplitudes from 24 …
[HTML][HTML] Preclinical assessment of CNS drug action using eye movements in mice
The drug development process for CNS indications is hampered by a paucity of preclinical
tests that accurately predict drug efficacy in humans. Here, we show that a wide variety of …
tests that accurately predict drug efficacy in humans. Here, we show that a wide variety of …