The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture
healing. Macrophages play a key role in the process of fracture healing by undergoing …

Atherosclerotic cardiovascular disease (ACVD) is an inflammatory disease of the coronary
arteries associated with atheroma formation, which can cause disability and often death …

Skeletal stem cells (SSCs) that are the major source of osteoblasts and adipocytes in adult
bone marrow express leptin receptor (LepR). To test whether LepR regulates SSC function …

Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of
populations worldwide. Changed bone metabolism is one of the important long-term …

Cellular senescence plays an important role in human diseases, including osteoporosis and
osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory …

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease known by the presence of
elevated blood glucose levels. Nowadays, it is perceived as a worldwide epidemic, with a …

The skeleton is a dynamic and metabolically active organ with the capacity to influence
whole body metabolism. This newly recognized function has propagated interest in the …

Mesenchymal stem cell (MSC) therapy is an emerging treatment strategy to counteract
metabolic syndromes, including obesity and its comorbid disorders. However, its …