Antimicrobial potential of naturally occurring bioactive secondary metabolites

KS Allemailem - Journal of Pharmacy and Bioallied Sciences, 2021 - journals.lww.com
The use of traditional medicines of natural origin has been prevalent since ancient times
globally as the plants produce a great diversity in their secondary metabolites. The naturally …

Antimicrobial, anti-biofilm, and anti-proliferative activities of lipopeptide biosurfactant produced by Acinetobacter junii B6

M Ohadi, H Forootanfar, G Dehghannoudeh… - Microbial …, 2020 - Elsevier
Lipopeptide biosurfactants (LPBs) are amphiphilic compounds produced by microorganisms
exhibiting various biological activities. The main aim of the present study was to assess the …

Synthesis, molecular docking and QSAR study of thiazole clubbed pyrazole hybrid as α-amylase inhibitor

M Duhan, R Singh, M Devi, J Sindhu… - Journal of …, 2021 - Taylor & Francis
In search of potent α-amylase inhibitors, herein we report the synthesis, molecular docking
and QSAR study of some thiazole clubbed pyrazole hybrids (TCPH) ie, 1-((1-phenyl-3-aryl-1 …

Antifungal activity of lipopeptides from Bacillus amyloliquefaciens MG3 against Colletotrichum gloeosporioides in loquat fruits

F Yan, C Li, X Ye, Y Lian, Y Wu, X Wang - Biological Control, 2020 - Elsevier
This work aims to produce and purify antifungal lipopeptides from fermentation by B.
amyloliquefaciens MG3, and verify antifungal mechanism on C. gloeosporioides. Using …

Mapping the structure–activity landscape of non-canonical peptides with MAP4 fingerprinting

E López-López, O Robles, F Plisson… - Digital …, 2023 - pubs.rsc.org
Peptide structure–activity/property relationship (P-SA/PR) studies focus on understanding
how the structural variations of peptides influence their biological activities and other …

Designing anti-microbial peptides against major β-lactamase enzymes in clinically important gram-negative bacterial pathogens: an in-silico study

S Basu, SM Joshi, S Ramaiah, A Anbarasu - Probiotics and Antimicrobial …, 2022 - Springer
Anti-microbial resistance (AMR) creating healthcare concerns worldwide requires ardent
exploration of therapeutic alternatives. Although anti-microbial peptides (AMP) are popular …

Computational investigation of imidazopyridine analogs as protein kinase B (Akt1) allosteric inhibitors by using 3D-QSAR, molecular docking and molecular dynamics …

X Gu, Y Wang, M Wang, J Wang, N Li - Journal of Biomolecular …, 2021 - Taylor & Francis
Abstract Protein kinase B (Akt1), which is a pivotal node in various cellular signaling
pathways and up-regulated in many human tumors, has been regarded as a promising …

Insights into mode of action mediated responses following pharmaceutical uptake and accumulation in plants

AL Garduño-Jimenez, LJ Carter - Frontiers in Agronomy, 2024 - frontiersin.org
The reuse of wastewater to meet irrigation requirements and slurries, sludges and manures
as fertilisers to meet crop nutrient demands inadvertently introduces human and veterinary …

New N-terminal fatty-acid-modified melittin analogs with potent biological activity

S Huang, G Su, S Jiang, L Chen, J Huang… - International Journal of …, 2024 - mdpi.com
Melittin, a natural antimicrobial peptide, has broad-spectrum antimicrobial activity. This has
resulted in it gaining increasing attention as a potential antibiotic alternative; however, its …

Computation-directed molecular design, synthesis, and fungicidal activity of succinate dehydrogenase inhibitors

K Li, S Hong, Z Yu, Z Hong, Y Sun… - Journal of Agricultural …, 2023 - ACS Publications
Succinate dehydrogenase inhibitors (SDHIs) are a class of fungicides targeting the
pathogenic fungi mitochondrial SDH. Here, molecular docking, three-dimensional …