Simple Summary The fusion between sperm and oocyte results in a zygote, which is a single
totipotent cell with the ability to develop into a functional organism. Totipotent cells can give …

Pre-implantation mammalian development unites extreme plasticity with a robust outcome:
the formation of a blastocyst, an organised multi-layered structure ready for implantation …

Previous work from our laboratory demonstrated the existence of miRNAs in human follicular
fluid. In the current study, we have sought to identify miRNAs that might affect oocyte/embryo …

The self-organisation of a fertilised egg to form a blastocyst structure, which consists of three
distinct cell lineages (trophoblast, epiblast and hypoblast) arranged around an off-centre …

The inner cell mass (ICM) of mammalian blastocysts consists of pluripotent epiblast and
hypoblast lineages, which develop into embryonic and extraembryonic tissues, respectively …

Early mammal embryogenesis starts with oocyte fertilization, giving rise to the zygote. The
events that the newly formed zygote surpasses are crucial to the embryo developmental …

Background This study describes the generation and analysis of the transcriptional profile of
bovine inner cell mass (ICM) and trophectoderm (TE), obtained from in vivo developed …

Background The segregation of the hypoblast and the emergence of the pluripotent epiblast
mark the final stages of blastocyst formation in mammalian embryos. In bovine embryos the …

Mammalian blastocysts comprise three distinct lineages, namely, trophoblast, hypoblast,
and epiblast, which develop into fetal placenta, extraembryonic yolk sac, and embryo …

Embryonic pluripotent stem cells (ePSCs) can generate all somatic cell types, as well as
functional gametes. In mouse and rat, derivation of ePSCs from the early epiblast is …