Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …

The ATPase valosin-containing protein (VCP)/p97 has emerged as a central and important
element of the ubiquitin system. Together with a network of cofactors, it regulates an ever …

Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …

The cytotoxicity of DNA-protein crosslinks (DPCs) is largely ascribed to their ability to block
the progression of DNA replication. DPCs frequently occur in cells, either as a consequence …

Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential
chromatin transactions, such as replication and transcription. Little was known about DPC …

Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA
replication, providing a molecular platform that facilitates the myriad protein–protein and …

DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in …

Toxic DNA-protein crosslinks (DPCs) arise by ionizing irradiation and UV light, are
particularly caused by endogenously produced reactive compounds such as formaldehyde …

p97/VCP (known as Cdc48 in S. cerevisiae or TER94 in Drosophila) is one of the most
abundant cytosolic ATPases. It is highly conserved from archaebacteria to eukaryotes. In …

Preservation of genome integrity is an essential process for cell homeostasis. During the
course of life of a single cell, the genome is constantly damaged by endogenous and …