Recent advancements in genetic and proteomic technologies have revealed that more of the
genome encodes proteins than originally thought possible. Specifically, some putative long …

Germ cell development creates totipotency through genetic as well as epigenetic regulation
of the genome function. Primordial germ cells (PGCs) are the first germ cell population …

Mitochondria are known to be functional organelles, but their role as a signaling unit is
increasingly being appreciated. The identification of a short open reading frame (sORF) in …

Around 98% of all transcriptional output in humans is non-coding RNA. RNA-mediated gene
regulation is widespread in higher eukaryotes and complex genetic phenomena like RNA …

The epigenetic profile of germ cells, which is defined by modifications of DNA and
chromatin, changes dynamically during their development. Many of the changes are …

The regulated migration of cells is essential for development and tissue homeostasis, and
aberrant cell migration can lead to an impaired immune response and the progression of …

Germ cells play a unique role in gamete production, heredity and evolution. Therefore, to
understand the mechanisms that specify germ cells is a central challenge in developmental …

Germline stem cells play a pivotal role in gametogenesis; yet little is known about how they
are formed, how they divide to self-renew, and how these processes are genetically …

Genetic and epigenetic mechanisms regulate the transition from the totipotent zygote to
pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts. These …

The central dogma of biology holds that genetic information normally flows from DNA to RNA
to protein. As a consequence it has been generally assumed that genes generally code for …