Reactive oxygen metabolites have multifactorial effects on the regulation of cell growth and
the capacity of malignant cells to invade. Overexpression of the superoxide dismutases …

Tumor formation arises as a consequence of alterations in the control of cell proliferation
and disorders in the interactions between ceils and their surroundings that result in invasion …

Background Microcell-mediated transfer of chromosome 6 into human C8161 and MelJuSo
melanoma cells suppresses their ability to metastasize by at least 95% without affecting their …

Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic
physiological changes in response to Arctic climates and a hyperlipid diet of primarily …

The development and progression of cancer1–3 and the experimental reversal of
tumorigenicity4, 5 are accompanied by complex changes in patterns of gene expression …

Introduction of a normal human chromosome 6 into human melanoma cell lines results in
suppression of tumorigenicity. This suggests that a gene (s) on chromosome 6 controls the …

In an effort to identify tumor suppressor gene (s) associated with the frequent loss of
heterozygosity observed on chromosome 6q25–q27, we constructed a contig derived from …

Chromosome 6-mediated suppression of tumorigenicity in malignant melanoma cell lines
provides a model system to identify genes associated with the reversion of the tumorigenic …

Abstract PLATELET-activating factor (PAF), a unique phospholipid mediator, possesses
potent proinflammatory, smooth-muscle contractile and hypotensive activities, and appears …

Current cancer therapies are highly toxic and often nonspecific. A potentially less toxic
approach to treating this prevalent disease employs agents that modify cancer cell …