Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and
continues to portend poor survival, despite multimodal treatment using surgery and …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy is a highly dynamic and multi-step process, regulated by many functional protein
units. Here, we have built up a comprehensive and up-to-date annotated gene list for the …

Autophagy, a main intracellular catabolic process, is induced in response to a variety of
cellular stresses to promptly degrade harmful agents and to coordinate the activity of …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

With global population aging, age-related diseases, especially sarcopenia, have attracted
much attention in recent years. Characterized by low muscle strength, low muscle quantity or …

Autophagy is a common name for a number of catabolic processes, which keep the cellular
homeostasis by removing damaged and dysfunctional intracellular components. Impairment …

Molecular chaperone HSP70s are attractive targets for cancer therapy, but their substrate
broadness and functional non-specificity have limited their role in therapeutical success …