Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene
expression. AS misregulation, caused by either dysregulation or mutation of splicing factors …

Endogenous retroelements (EREs), which comprise half of the human genome, play a
pivotal role in genome dynamics. Some EREs retained the ability to encode proteins …

Circular RNAs (circRNA) contribute to cancer stemness, proliferation, and metastasis. The
biogenesis of circRNAs can be impacted by the genetic landscape of tumors. Herein, we …

Pre-mRNA splicing is a process used by eukaryotic cells to generate messenger RNAs that
can be translated into proteins. During splicing, the non-coding regions of the RNAs (introns) …

With the advent of immunotherapeutics, a new era in the combat against cancer has begun.
Particularly promising are neo-epitope-targeted therapies as the expression of neo-antigens …

Prolactin (PRL) is elevated in B-cell-mediated lymphoproliferative diseases and promotes B-
cell survival. Whether PRL or PRL receptors drive the evolution of B-cell malignancies is …

Splicing modulation by a small compound offers therapeutic potential for diseases caused
by splicing abnormality. However, only a few classes of compounds that can modulate …

Despite significant interest in therapeutic targeting of splicing, few chemical probes are
available for the proteins involved in splicing. Here, we show that elaborated stereoisomeric …

Leukemia represents the most prevalent malignancy in children, constituting 30% of
childhood cancer cases, with acute lymphoblastic leukemia (ALL) being particularly …