Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …

Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …

Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …

Background Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory
premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells …

Somatic or acquired mutations are postzygotic genetic variations that can occur within any
tissue. These mutations accumulate during aging and have classically been linked to …

The pathophysiology of vascular disease is linked to accelerated biological aging and a
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …

Cancer is the second leading cause of death in people with chronic kidney disease (CKD)
after cardiovascular disease. The incidence of CKD in patients with cancer is higher than in …

ABSTRACT Rationale and Objective Clonal hematopoiesis of indeterminate potential
(CHIP), defined by the age-related ontogenesis of expanded leukemogenic mutations …

Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …