Challenges and Prospects of DNA-Encoded Library Data Interpretation
M Wichert, L Guasch, RM Franzini - Chemical Reviews, 2024 - ACS Publications
DNA-encoded library (DEL) technology is a powerful platform for the efficient identification of
novel chemical matter in the early drug discovery process enabled by parallel screening of …
novel chemical matter in the early drug discovery process enabled by parallel screening of …
Positive allosteric modulation of µ-opioid receptor–A new possible approach in the pain management?
W Król, W Machelak, M Zielińska - Biochemical Pharmacology, 2024 - Elsevier
The antinociceptive effect of the opioid drugs is achieved through activation of the µ-opioid
receptor (MOP). The orthosteric and allosteric sites of opioid receptors may be modulated …
receptor (MOP). The orthosteric and allosteric sites of opioid receptors may be modulated …
Opioid crisis: compound opens up potential strategy to tackle overdoses
CM Cahill - 2024 - nature.com
Opioid crisis: compound opens up potential strategy to tackle overdoses Skip to main content
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Thank you for visiting nature.com. You are using a browser version with limited support for …
Slow dissociation kinetics of fentanyls and nitazenes correlates with reduced sensitivity to naloxone reversal at the μ‐opioid receptor
N Alhosan, D Cavallo, M Santiago… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Fentanyls and nitazenes are μ‐opioid receptor agonists
responsible for a large number of opioid overdose deaths. Here, we determined the potency …
responsible for a large number of opioid overdose deaths. Here, we determined the potency …
Structure–Activity Relationships and Molecular Pharmacology of Positive Allosteric Modulators of the Mu-Opioid Receptor
M Li, X Gan, K Liu, R Walajapet… - ACS Chemical …, 2024 - ACS Publications
Positive allosteric modulation of the mu-opioid receptor is a promising strategy to address
the ever-growing problem of acute and chronic pain management. Positive allosteric …
the ever-growing problem of acute and chronic pain management. Positive allosteric …
Selenium (II)‐Nitrogen Exchange (SeNEx) Chemistry: A Good Chemistry Suitable for Nanomole‐Scale Parallel Synthesis, DNA‐encoded Library Synthesis and …
W Hou, S Hou, Y Gu, S Zhang, P Ma, HY Hu… - …, 2024 - Wiley Online Library
The continuous development of click reactions with new connecting linkage is crucial for
advancing the frontiers of click chemistry. Selenium‐nitrogen exchange (SeNEx) chemistry …
advancing the frontiers of click chemistry. Selenium‐nitrogen exchange (SeNEx) chemistry …
De novo Design of A Fusion Protein Tool for GPCR Research
K Gao, X Zhang, J Nie, H Meng, W Zhang, B Tian, X Liu - bioRxiv, 2024 - biorxiv.org
G protein-coupled receptors (GPCRs) play pivotal roles in cellular signaling and represent
prominent drug targets. Structural elucidation of GPCRs is crucial for drug discovery efforts …
prominent drug targets. Structural elucidation of GPCRs is crucial for drug discovery efforts …
Ligand-Free Signaling of G Protein Coupled Receptors: Addressing Unresolved questions with Antagonist Probes and Genomics
W Sadee - Medical Research Archives, 2024 - esmed.org
G protein coupled receptors (GPCRs) exist each in multiple forms and aggregates
distributed across various cell compartments, signaling along multiple pathways upon …
distributed across various cell compartments, signaling along multiple pathways upon …
Enhancing naloxone
JF Foley - Science Signaling, 2024 - science.org
Enhancing naloxone | Science Signaling news careers commentary Journals Science Science
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