Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …

The mTOR pathway has a central role in the regulation of cell metabolism, growth and
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …

The mammalian target of rapamycin (mTOR) has emerged as a potential target for drug
development, particularly due to the fact that it plays such a crucial role in cancer biology. In …

Dendrite pathology and synapse disassembly are critical features of chronic
neurodegenerative diseases. In spite of this, the capacity of injured neurons to regenerate …

Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential
process for mammalian cell survival. An enzyme responsible for this process, sodium …

Significance: Autophagy is emerging as an important pathway in many biological processes
and diseases. This review summarizes the current progress on the role of autophagy in …

Sunitinib, a multitargeted receptor tyrosine kinase inhibitor including vascular endothelial
growth factor, has been widely used as a first‐line treatment against metastatic renal cell …

Purpose: ABTL0812 is a novel first-in-class, small molecule which showed antiproliferative
effect on tumor cells in phenotypic assays. Here we describe the mechanism of action of this …

Several elements highlight the importance of the mechanistic target of rapamycin (mTOR) in
the biology of renal cell carcinoma (RCC). mTOR signaling pathway is indeed frequently …

Background Meningioma is the most frequent primary intracranial tumour. Surgical resection
remains the main therapeutic option as pharmacological intervention is hampered by poor …