Manganese (Mn) is an essential element required for many physiological functions. While it
is essential at physiological levels, excessive accumulation of Mn in the brain causes severe …

Manganese (M n) is an essential trace element that is required for maintaining proper
function and regulation of numerous biochemical and cellular reactions. Despite its …

Background It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in
the regulation of food intake and body weight by controlling the excitability, plasticity and the …

In midbrain tectum (MT) structures, such as the dorsal periaqueductal gray (dPAG), the
superior colliculus (SC) and the inferior colliculus (IC) GABAergic neurons exert a tonic …

Deep layers of the superior colliculus, the dorsal periaqueductal gray matter and the inferior
colliculus are midbrain structures involved in the generation of defensive behavior and fear …

ETHNOPHARMACOLOGICAL RELEVANCE: The Q'eqchi'Maya possess a large selection of
plants to treat neurological disorders, including epilepsy and susto (fright), a culture-bound …

Invertebrate venoms have attracted considerable interest as a potential source of bioactive
substances, especially neurotoxins. These molecules have proved to be extremely useful …

The neuropsychopharmacological basis of fear‐or panic‐related behavior has been the
focus of several studies. Some mesencephalic tectum (MT) structures, such as the superior …

Although most genetic association studies are performed with the intention of detecting
nucleotide polymorphisms that are correlated with a complex trait, transcript abundance …

Mass spectrometric (MS) binding assays, a powerful tool to determine affinities of single
drug candidates toward chosen targets, were recently demonstrated to be suitable for the …