Role of polyphenols in combating Type 2 Diabetes and insulin resistance
Compromised carbohydrate metabolism leading to hyperglycemia is the primary metabolic
disorder of non-insulin-dependent diabetes mellitus. Reformed digestion and altered …
disorder of non-insulin-dependent diabetes mellitus. Reformed digestion and altered …
Melatonin: A mitochondrial resident with a diverse skill set
Melatonin is an ancient molecule that originated in bacteria. When these prokaryotes were
phagocytized by early eukaryotes, they eventually developed into mitochondria and …
phagocytized by early eukaryotes, they eventually developed into mitochondria and …
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch
E Fernandez-Vizarra, S Lopez-Calcerrada… - Cell Metabolism, 2022 - cell.com
The structural and functional organization of the mitochondrial respiratory chain (MRC)
remains intensely debated. Here, we show the co-existence of two separate MRC …
remains intensely debated. Here, we show the co-existence of two separate MRC …
A review of medicinal plants of the himalayas with anti-proliferative activity for the treatment of various cancers
H Regassa, A Sourirajan, V Kumar, S Pandey… - Cancers, 2022 - mdpi.com
Simple Summary Drugs are used to treat cancer. Most drugs available in the market are
chemosynthetic drugs and have side effects on the patient during and after the treatment, in …
chemosynthetic drugs and have side effects on the patient during and after the treatment, in …
Discovery of the 3-amino-1, 2, 4-triazine-based library as selective PDK1 inhibitors with therapeutic potential in highly aggressive pancreatic ductal adenocarcinoma
D Carbone, M De Franco, C Pecoraro… - International Journal of …, 2023 - mdpi.com
Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that are directly
involved in altered cancer cell metabolism, resulting in cancer aggressiveness and …
involved in altered cancer cell metabolism, resulting in cancer aggressiveness and …
The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat
PW Stacpoole, CE McCall - Mitochondrion, 2023 - Elsevier
Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …
Melatonin and pathological cell interactions: Mitochondrial glucose processing in cancer cells
Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …
Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4
Identifying novel molecules as potential kinase inhibitors are gaining significant attention
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …
globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity …
Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial
cells undergo a reversible phenotype switch via the loss of adhesion capacity and …
cells undergo a reversible phenotype switch via the loss of adhesion capacity and …
Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis
(conversion of glucose to lactate in the presence of oxygen) for their energy requirements. In …
(conversion of glucose to lactate in the presence of oxygen) for their energy requirements. In …