Mortality caused by age-related bone fractures or osteoporosis is steadily increasing
worldwide as the population ages. The pace of the development of bone regeneration …

Within the eukaryotic nucleus the genomic DNA is organized into chromatin by stably
interacting with the histone proteins as well as with several other nuclear components …

Poor tendon repair is often a clinical challenge due to the lack of ideal biomaterials.
Electrospun aligned fibers, resembling the ultrastructure of tendon, have been previously …

Background: Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate,
are the main products of microbial fermentation in the gut and might mediate some of the …

In utero exposure to the ubiquitous plasticizer, bisphenol A (BPA) is associated with
offspring obesity. As adipogenesis is a critical factor contributing to obesity, we determined …

Adipose-derived mesenchymal stem cells (ASCs) represent a valid therapeutic option for
clinical application in several diseases, due to their ability to repair damaged tissues and to …

Most cells in the human body, including human mesenchymal stem cells (hMSCs), have
evolved to survive and function in a low physiological oxygen (O2) environment …

Adipocytes play an essential role in maintaining energy homeostasis in mammals. The
primary function of white adipose tissue (WAT) is to store energy; for brown adipose tissue …

Premature ovarian failure (POF) is one of the main causes of infertility in women under the
age of 40 years. Recently, epigenetic reprogramming, particularly DNA hypomethylation …

Mesenchymal stemXin cells (MSCs) are a great cell source for bone regeneration. Although
combining MSCs with growth factors and scaffolds provides a useful clinical strategy for …