CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …

CD36, a scavenger receptor expressed in multiple cell types, mediates lipid uptake,
immunological recognition, inflammation, molecular adhesion, and apoptosis. CD36 is a …

Abstract Background Tumor associated macrophages (TAMs) are present in high density in
solid tumors. TAMs share many characteristics with alternatively activated macrophages …

Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and
ATP synthesis but also cause serious stress to various tissues, contributing to the …

Macrophage uptake of oxidized low-density lipoprotein (oxLDL) is thought to play a central
role in foam cell formation and the pathogenesis of atherosclerosis. We demonstrate here …

J. Clin. Invest. 108: 785–791 (2001). DOI: 10.1172/JCI200114006. some basic structure-
function information. Amino acids 93–120 define a minimal high-affinity binding site for TSP …

Rationale: NR4A1 (Nur77) is a nuclear receptor that is expressed in macrophages and
within atherosclerotic lesions, yet its function in atherosclerosis is unknown. Objective …

Macrophage scavenger receptors have been implicated as key players in the pathogenesis
of atherosclerosis. To assess the role of the class B scavenger receptor CD36 in …

The ontogeny of airway macrophages (AMs) in human lung and their contribution to disease
are poorly mapped out. In mice, aging is associated with an increasing proportion of …

Macrophage polarization is influenced by lipids, which also exert significant control over
macrophage functions. Lipids and their metabolites are players in intricate signaling …