J Wang, Y Li - Theranostics, 2019 - ncbi.nlm.nih.gov
CD36, a scavenger receptor expressed in multiple cell types, mediates lipid uptake, immunological recognition, inflammation, molecular adhesion, and apoptosis. CD36 is a …
M Genin, F Clement, A Fattaccioli, M Raes, C Michiels - BMC cancer, 2015 - Springer
Abstract Background Tumor associated macrophages (TAMs) are present in high density in solid tumors. TAMs share many characteristics with alternatively activated macrophages …
Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and ATP synthesis but also cause serious stress to various tissues, contributing to the …
Macrophage uptake of oxidized low-density lipoprotein (oxLDL) is thought to play a central role in foam cell formation and the pathogenesis of atherosclerosis. We demonstrate here …
M Febbraio, DP Hajjar… - The Journal of clinical …, 2001 - Am Soc Clin Investig
J. Clin. Invest. 108: 785–791 (2001). DOI: 10.1172/JCI200114006. some basic structure- function information. Amino acids 93–120 define a minimal high-affinity binding site for TSP …
RN Hanna, I Shaked, HG Hubbeling, JA Punt… - Circulation …, 2012 - Am Heart Assoc
Rationale: NR4A1 (Nur77) is a nuclear receptor that is expressed in macrophages and within atherosclerotic lesions, yet its function in atherosclerosis is unknown. Objective …
M Febbraio, EA Podrez, JD Smith… - The Journal of …, 2000 - Am Soc Clin Investig
Macrophage scavenger receptors have been implicated as key players in the pathogenesis of atherosclerosis. To assess the role of the class B scavenger receptor CD36 in …
The ontogeny of airway macrophages (AMs) in human lung and their contribution to disease are poorly mapped out. In mice, aging is associated with an increasing proportion of …
Macrophage polarization is influenced by lipids, which also exert significant control over macrophage functions. Lipids and their metabolites are players in intricate signaling …