The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

The endothelial monolayer partitioning underlying tissue from blood components in the
vessel wall maintains tissue fluid balance and host defense through dynamically opening …

Unchecked inflammation is a hallmark of inflammatory tissue injury in diseases such as
acute respiratory distress syndrome (ARDS). Yet the mechanisms of inflammatory lung injury …

Vascular permeability is a highly coordinated process that integrates vesicular trafficking,
complex junctional rearrangements, and refined cytoskeletal dynamics. In response to the …

One biofabrication process that has gained tremendous momentum in the field of tissue
engineering and regenerative medicine is cell-printing or most commonly bioprinting. We …

Small G proteins exist in eukaryotes from yeast to human and constitute the Ras superfamily
comprising more than 100 members. This superfamily is structurally classified into five …

Acute lung injury (ALI) is a severe form of hypoxic lung disease responsible for a large
number of deaths worldwide. Despite recent advances in supportive care, no reduction in …

Rationale: Increased endothelial permeability and defective repair are the hallmarks of
several vascular diseases, including acute lung injury. However, little is known about the …

Alveolar macrophages (AMs), upon sensing pathogens, trigger host defense by activating
toll-like receptor 4 (TLR4), but the counterbalancing mechanisms that deactivate AM …

Within blood vessels, endothelial cell–cell and cell–matrix adhesions are crucial to preserve
barrier function, and these adhesions are tightly controlled during vascular development …