Type 2 diabetes mellitus is a pathology of heterogeneous etiology characterized by
hyperglycemia resulting from lack of insulin action, insulin secretion, or both, and the …

Various internal and external factors negatively affect the homeostatic equilibrium of
organisms at the molecular to the whole-body level, inducing the so-called state of stress …

Background & aims Chronic kidney disease (CKD) patients have numerous complications
associated with inflammation, which is a potential driver for cardiovascular disease …

Growing evidence indicates that oxidative and endoplasmic reticular stress, which trigger
changes in ion channels and inflammatory pathways that may undermine cellular …

Background Diabetic nephropathy (DN) is a lethal diabetic microvascular complication
characterized by chronic low-grade inflammation. The NOD-like receptor pyrin domain …

Introduction As a lytic inflammatory cell death, pyroptosis has been recently described but
has not been unequivocally elucidated in diabetic nephropathy (DN). VX‐765 is a safe and …

Pyroptosis is a pattern of programmed cell death that significantly differs from apoptosis and
autophagy in terms of cell morphology and function. The process of pyroptosis is …

The innate immune system contains multiple classes of pattern recognition receptors
(PRRs), which recognize pathogen‐associated molecular patterns (PAMPs) and danger …

Nucleotide-binding oligomerization domain-like receptors (NLRs), including NLRAs, NLRBs
(also known as NAIPs), NLRCs, and NLRPs, are a major subfamily of pattern recognition …

Inflammasome-driven release of interleukin (IL)-1β is a central element of many forms of
sterile inflammation and has been evident to promote the onset and progression of diabetic …