Mutationally activated RAS proteins are critical oncogenic drivers in nearly 30% of all human
cancers. As with mutant RAS, the role of wild type RAS proteins in oncogenesis, tumour …

Publisher Summary Chemical carcinogenesis research has substantially broadened the
understanding of the cellular and molecular changes involved in cancer development and …

Cellular proto-oncogenes can be activated by both point mutations and chromosomal
translocations, suggesting that there may be a direct link between exposure to agents which …

The neu oncogene, which is frequently activated in neuro-and glloblastomas of BDIX rats,
was originally identified in the NIH 3T3 focus-forming assay. cDNA clones of the normal and …

The mammalian ras gene family encodes key cell-signaling, cell growth-related proteins that
have been highly conserved in species from yeast to man. Specific point mutations in the ras …

Initiation of tumorigenesis in mouse skin can be accomplished by mutagenesis of the H-ras
gene by treatment with chemical carcinogens. A mouse model system has been developed …

We compared the expression of the ras gene family (H-ras, K-ras, and N-ras) in adult mouse
tissues and during development. We found substantial variations in expression among …

Genes that can inhibit the expression of the tumorigenic phenotype have been detected by
the fusion of normal and malignant cells, the phenotypic reversion of in vitro transformants …

Caveolin-1 is a principal component of caveolae membranes in vivo. Caveolin-1 mRNA and
protein expression are down-regulated in NIH 3T3 cells in response to transformation by …

Kras is the most frequently mutated ras family member in lung carcinomas,, whereas Hras
mutations are common in tumors from stratified epithelia such as the skin. Using a Hras …