The TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53
suppresses tumorigenesis by transcriptionally regulating a network of target genes that play …

The tumour suppressor TP53 is a master regulator of several cellular processes that
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …

The first cell fate commitment during mammalian development is the specification of the
inner cell mass and trophectoderm. This irreversible cell fate commitment should be …

Summary p53, master transcriptional regulator of the genotoxic stress response, controls cell-
cycle arrest and apoptosis following DNA damage. Here, we identify a p53-induced lncRNA …

The frequency of p53 mutations in colorectal cancer (CRC) is approximately 40–50%. A
variety of therapies are being developed to target tumors expressing mutant p53. However …

In lung adenocarcinoma (LUAD), loss-of-function mutations in the splicing factor RBM10
frequently co-occur with oncogenic EGFR mutations. A detailed understanding of the …

The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the
regulation of several cellular functions, including cell cycle progression and cell death in …

TP53, encoding the p53 transcription factor, is the most frequently mutated tumor suppressor
gene across all human cancer types. While p53 has long been appreciated to induce …

The p53 transcription factor drives anti-proliferative gene expression programs in response
to diverse stressors, including DNA damage and oncogenic signaling. Here, we seek to …

TP53 is the most frequently mutated gene in cancer, yet key target genes for p53-mediated
tumor suppression remain unidentified. Here, we characterize a rare, African-specific …