Computational systems biology approaches to anti-angiogenic cancer therapeutics

SD Finley, LH Chu, AS Popel - Drug discovery today, 2015 - Elsevier
Highlights•Systems biology approaches support drug development efforts.•Models of
angiogenesis aid in testing anti-angiogenic therapeutic strategies.•Models provide novel …

A passage through systems biology to systems medicine: adoption of middle-out rational approaches towards the understanding of therapeutic outcomes in cancer

D Majumder, A Mukherjee - Analyst, 2011 - pubs.rsc.org
During the last few decades, conventional practices in medicine including oncology focus
their interests towards the reductionism of molecular detailing and at the analytical level …

[PDF][PDF] Multi-scale modeling approaches in systems biology towards the assessment of cancer treatment dynamics: adoption of middle-out rationalist approach

D Majumder, A Mukherjee - Advances in Cancer Research & …, 2013 - ibimapublishing.com
Complex diseases like cancer are being viewed through the recent approach of systems
biology (SB) with a hope that it could provide a better assessment about the disease …

Efficacy and toxicity assessment of different antibody based antiangiogenic drugs by computational docking method

S Mukherjee, G Chatterjee, M Ghosh… - Advances in …, 2016 - Wiley Online Library
Bevacizumab and trastuzumab are two antibody based antiangiogenic drugs that are in
clinical practice for the treatment of different cancers. Presently applications of these drugs …

A composite synergistic systems model for exploring the efficacies of different chemotherapeutic strategies in cancer

PK Dhar, D Majumder - Computational Biology Journal, 2013 - Wiley Online Library
Different chemotherapeutic strategies like Maximum Tolerable Dosing (MTD), Metronomic
Chemotherapy (MCT), and Antiangiogenic (AAG) drug are available; however, the selection …

An Analytical Approach for the Determination of Chemotherapeutic Drug Application Trade-Offs in Leukemia

PK Dhar, TK Naskar, D Majumder - Smart and Innovative Trends in Next …, 2018 - Springer
For the treatment of different leukemia different chemotherapies are available. However the
success rate of any particular drug scheduling may vary with leukemic condition. In general …

[PDF][PDF] Efficacy and toxicity assessment of different clinically used small molecular tyrosine kinase inhibitors by computational molecular docking method

G Chatterjee, S Mukherjee, D Majumder - J Metabol Sys Biol, 2016 - researchgate.net
Along with the antibody based antiangiogenic (AAG) drugs, several small molecular
antiangiogenic (sAAG) drugs are also in clinical practice for the treatment of different …

[PDF][PDF] Research Article A Composite Synergistic Systems Model for Exploring the Efficacies of Different Chemotherapeutic Strategies in Cancer

PK Dhar, D Majumder - 2013 - academia.edu
Different chemotherapeutic strategies like Maximum Tolerable Dosing (MTD), Metronomic
Chemotherapy (MCT), and Antiangiogenic (AAG) drug are available; however, the selection …