In this review, we provide a summary of the state-of-the-art in the in silico modelling of
cerebral blood flow (CBF) and its application in in silico clinical trials. CBF plays a key role in …

Cerebral perfusion modelling is a promising tool to predict the impact of acute ischaemic
stroke treatments on the spatial distribution of cerebral blood flow (CBF) in the human brain …

An in silico trial simulates a disease and its corresponding therapies on a cohort of virtual
patients to support the development and evaluation of medical devices, drugs, and …

Computational physiological models are promising tools to enhance the design of clinical
trials and to assist in decision making. Organ-scale haemodynamic models are gaining …

The microvasculature plays a key role in oxygen transport in the mammalian brain. Despite
the close coupling between cerebral vascular geometry and local oxygen demand, recent …

Many ischaemic stroke patients who have a mechanical removal of their clot (thrombectomy)
do not get reperfusion of tissue despite the thrombus being removed. One hypothesis for this …

Understanding the correlation between pathological changes and the type of brain injury is
pivotal in mitigating the damage and planning reliable and improved treatment strategies …

Treating retinal diseases to prevent sight loss is an increasingly important challenge. Thanks
to the configuration of the eye, the retina can be examined relatively easily in situ. Owing to …

Background and objective: Oxygen is carried to the brain by blood flow through generations
of vessels across a wide range of length scales. This multi-scale nature of blood flow and …

The presence of collaterals and high thrombus permeability are associated with good
functional outcomes after an acute ischaemic stroke. We aim to understand the combined …