Infectious diseases are the second most important cause of human death worldwide;
Staphylococcus aureus (S. aureus) is a very common human pathogenic microorganism that …

Seven mobile oxazolidinone resistance genes, including cfr, cfr (B), cfr (C), cfr (D), cfr (E),
optrA, and poxtA, have been identified to date. The cfr genes code for 23S rRNA methylases …

The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the
treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind …

Reports of transmissible colistin resistance show the importance of comprehensive colistin
resistance surveillance. Recently, a new allele of the mobile colistin resistance (mcr) gene …

Enterococci are a part of human microbiota and a leading cause of multidrug resistant
infections. Here, we identify a family of Enterococcus pore-forming toxins (Epxs) in E …

The presence of multi-drug resistant (MDR) bacteria in ready-to-eat foods comprises a threat
for public health due to their ability to acquire and transfer antibiotic-resistant determinants …

Introduction Enterococcus spp. have gradually evolved from commensals to causing life-
threatening hospital-acquired infections globally due to their inherent antimicrobial …

Linezolid-resistant Enterococcus faecalis (LREfs) carrying optrA are increasingly reported
globally from multiple sources, but we lack a comprehensive analysis of human and animal …

Objectives poxtA is the most recently described gene conferring acquired resistance to
linezolid, a relevant antibiotic for treating enterococcal infections. We retrospectively …

Enterococci are Gram-positive bacteria that have evolved to thrive as both commensals and
pathogens, largely due to their accumulation of mobile genetic elements via horizontal gene …