Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Direct fluoroalkoxylation reactions of (hetero) arenes, carbon‐carbon multiple bonds, and
substitution reactions at Csp3 carbon centers by CF3O, CHF2O, and (CF3) 2CFO groups are …

A carbene-catalyzed chemoselective reaction of unsymmetric enedials is disclosed. The
reaction provides a concise access to bicyclic furo [2, 3-b] pyrroles derivatives in excellent …

C–H late-stage functionalization has gradually become a powerful approach for the rapid
optimization of lead compounds' bioactivity. Significant advances in this field have been …

We highlight key contributions in the field of direct radical CAr− H (hetero) aromatic
functionalization involving fluorinated radicals. A compilation of Functional Group Transfer …

Trifluoromethoxylated aromatics (ArOCF3) are valuable structural motifs in the area of drug
discovery due to the enhancement of their desired physicochemical properties upon the …

A photoinitiated anti‐hydropentafluorosulfanylation of terminal alkynes using SF5Cl and
(TMS) 3SiH as the hydrogen atom donor is reported. This transformation generates …

Introduction Late-stage functionalization (LSF) allows for the introduction of new chemical
groups toward the end of a synthetic sequence, which means new molecules can be rapidly …

Radical trifluoromethoxylation is an attractive approach to prepare compounds featuring the
important OCF3 group, however most existing methods have focused on aromatic …

Comprehensive Summary The trifluoromethoxy functional group has received increasing
attention in recent years due to its distinctive properties such as good metabolic stability …