Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …

The traditional use of the yeast Saccharomyces cerevisiae in alcoholic fermentation has,
over time, resulted in substantial accumulated knowledge concerning genetics, physiology …

INTRODUCTION Metabolism is among the most strongly conserved processes across all
domains of life and is crucial for both bioengineering and disease research, yet we still have …

Phenylpropanoids comprise an important class of plant secondary metabolites. A number of
transcription factors have been used to upregulate-specific branches of phenylpropanoid …

Constraint-based models of metabolism are a widely used framework for predicting flux
distributions in genome-scale biochemical networks. The number of published methods for …

Eukaryotic cells execute complex transcriptional programs in which specific loci throughout
the genome are regulated in distinct ways by targeted regulatory assemblies. We have …

New synthetic biology capabilities hold the promise of dramatically improving our ability to
engineer biological systems. However, a fundamental hurdle in realizing this potential is our …

The rise of systems biology implied a growing demand for highly sensitive techniques for the
fast and consistent detection and quantification of target sets of proteins across multiple …

A method for performing untargeted metabolomic analysis of human serum has been
developed based on protein precipitation followed by Ultra Performance Liquid …

Direct in vivo investigation of mammalian metabolism is complicated by the distinct
metabolic functions of different tissues. We present a computational method that successfully …