The endoplasmic reticulum (ER) and mitochondria are tightly associated with very dynamic
platforms termed mitochondria-associated membranes (MAMs). MAMs provide an excellent …

Phosphatidylethanolamine (PE) is the second most abundant glycerophospholipid in
eukaryotic cells. The existence of four only partially redundant biochemical pathways that …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor
protein (APP) by γ‐secretase, via an unknown mechanism. We recently showed that …

In this study, we used cryoelectron microscopy to determine the structures of the Flotillin
protein complex, part of the Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) superfamily …

Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited
disorders in which lower extremity weakness and spasticity are the predominant symptoms …

More than a billion years ago, bacterial precursors of mitochondria became endosymbionts
in what we call eukaryotic cells today. The true significance of the word “endosymbiont” has …

In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid
precursor protein (APP) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment …

The fundamental framework of steroidogenesis is similar across steroidogenic cells,
especially in initial mitochondrial steps. For instance, the START domain containing protein …

Lipid rafts are plasma membrane microdomains enriched in cholesterol and sphingolipids
that are involved in the lateral compartmentalization of molecules at the cell surface …