Isoxazole derivatives as regulators of immune functions

M Zimecki, U Bąchor, M Mączyński - Molecules, 2018 - mdpi.com
In this review, we present reports on the immunoregulatory properties of isoxazole
derivatives classified into several categories, such as immunosuppressive, anti …

Recent advances in isoxazole chemistry

AV Galenko, AF Khlebnikov, MS Novikov… - Russian Chemical …, 2015 - iopscience.iop.org
The preparation methods and reactions of isoxazoles are described and systematized on
the basis of analysis of the literature published from 2005 to present. In the discussion of …

Direct synthesis of trisubstituted isoxazoles through gold-catalyzed domino reaction of alkynyl oxime ethers

M Ueda, A Sato, Y Ikeda, T Miyoshi, T Naito… - Organic …, 2010 - ACS Publications
Alkynyl oxime ether underwent a gold-catalyzed domino reaction involving cyclization and
subsequent Claisen-type rearrangement to afford trisubstituted isoxazoles in a direct …

Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability

B Nagaraju, J Kovvuri, CG Kumar, SR Routhu… - Bioorganic & medicinal …, 2019 - Elsevier
A series of new pyrazole linked benzothiazole-β-naphthol derivatives were designed and
synthesized using a simple, efficient and ecofriendly route under catalyst-free conditions in …

The main directions and recent trends in the synthesis and use of isoxazoles

OB Bondarenko, NV Zyk - Chemistry of Heterocyclic Compounds, 2020 - Springer
This review summarizes the main directions and recent trends in the synthesis of isoxazoles,
and also provides examples of the use of isoxazoles as biologically active compounds in …

Synthesis and anticancer activity of amide derivatives of 1, 2-isoxazole combined 1, 2, 4-thiadiazole

S Shahinshavali, R Sreenivasulu… - Russian Journal of …, 2019 - Springer
A series of amide derivatives of 1, 2-isoxazole combined with 1, 2, 4-thiadiazole are
synthesized 11a–11j. Their chemical structures are confirmed by 1 H and 13 C NMR, and …

An alkynyliodide cycloaddition strategy for the construction of iodoisoxazoles

JA Crossley, DL Browne - The Journal of Organic Chemistry, 2010 - ACS Publications
The thermally promoted cycloaddition between alkynyliodides and nitrile oxides is reported.
The process offers excellent regioselectivity and a broad scope with respect to both the …

Synthesis of 3,4,5‐Trisubstituted Isoxazoles from Morita–Baylis–Hillman Acetates by an NaNO2/I2‐Mediated Domino Reaction

SU Dighe, S Mukhopadhyay, S Kolle… - Angewandte …, 2015 - Wiley Online Library
Abstract An efficient NaNO2/I2‐mediated one‐pot transformation of Morita–Baylis–Hillman
(MBH) acetates into alkyl 3‐nitro‐5‐(aryl/alkyl) isoxazole‐4‐carboxylates is described. In a …

Palladium‐Catalyzed Direct C H Arylation of Isoxazoles at the 5‐Position

M Shigenobu, K Takenaka, H Sasai - Angewandte Chemie, 2015 - Wiley Online Library
A palladium‐catalyzed direct arylation of isoxazoles with aryl iodides has been achieved.
The C H bond at the 5‐position is activated selectively to give coupling products in …

Synthesis of 4, 5‐Dihydroisoxazoles by Condensation of Primary Nitro Compounds with Alkenes by Using a Copper/Base Catalytic System

L Cecchi, F De Sarlo, F Machetti - Chemistry–A European …, 2008 - Wiley Online Library
A new procedure for the synthesis of 4.5‐dihydroisoxazoles by condensation of primary nitro
compounds with olefins by using a copper/base catalytic system is described. The catalytic …