Lysine acetyltransferase (KAT) enzymes including the p300, MYST, and GCN5 families play
major roles in modulating the structure of chromatin and regulating transcription. Because of …

Acute myeloid leukemia (AML) is a common and catastrophic hematological neoplasm with
high mortality rates. Conventional therapies, including chemotherapy, hematopoietic stem …

Telomerase enables replicative immortality in most cancers including acute myeloid
leukemia (AML). Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in …

Acute myeloid leukemia (AML) is the most common hematopoietic malignancies, and
chemotherapy resistance is one of the main causes of relapse. Because of lower survival …

Cytotoxic chemotherapy remains a key modality in cancer treatment. These therapies,
successfully used for decades, continue to transform the lives of cancer patients daily. With …

For several decades, induction therapy with nucleoside analogs, in particular cytarabine
(Ara-C) and, to a lesser extent, fludarabine, has been the standard of care for patients …

Background The composition of the bone marrow immune microenvironment in patients with
acute myeloid leukaemia (AML) was analysed by single-cell sequencing and the …

Flavanone compounds are naturally occurring phytochemicals present in most of citrus fruits
reported to be a potential anticancer moiety as it majorly participates in the inhibition of the …

Augmented CD4+ T cell response in autoimmunity is characterized by extensive metabolic
reprogramming. However, the epigenetic molecule that drives the metabolic adaptation of …

Breast cancer is by far the most common cancer in women, and for a while, it surpassed lung
cancer as the most diagnosed cancer, regardless of gender, in 2020 [1]. Chemotherapy and …