The transforming growth factor-β (TGFβ) superfamily is encoded by 33 genes and includes
TGFβ, bone morphogenetic proteins (BMPs) and activins. Although TGFβ is well recognized …

The extracellular matrix is a complex network of hydrated macromolecular proteins and
sugars that, in concert with bound soluble factors, comprise the acellular stromal …

Basement membranes (BMs) are ubiquitous extracellular matrices whose composition
remains elusive, limiting our understanding of BM regulation and function. By developing a …

Completion of genome sequences for many organisms allows a reasonably complete
definition of the complement of extracellular matrix (ECM) proteins. In mammals this “core …

The extracellular matrix (ECM) and ECM proteins are important in phenomena as diverse as
developmental patterning, stem cell niches, cancer, and genetic diseases. The ECM has …

Bromine is ubiquitously present in animals as ionic bromide (Br−) yet has no known
essential function. Herein, we demonstrate that Br− is a required cofactor for peroxidasin …

It is widely acknowledged that integrins, the major receptors for the extracellular matrix
(ECM) proteins, exert an extensive crosstalk with many growth factor and cytokine receptors …

TGF-β superfamily signaling pathways emerged with the evolution of multicellular animals,
suggesting that these pathways contribute to the increased diversity and complexity required …

We show that endothelial cell (EC)–generated vascular guidance tunnels (ie, matrix spaces
created during tube formation) serve as conduits for the recruitment and motility of pericytes …

Extracellular matrix (ECM) is essential for all stages of angiogenesis. In the adult,
angiogenesis begins with endothelial cell (EC) activation, degradation of vascular basement …