The skin is the largest organ of the body and has a complex and very active structure that
contributes to homeostasis and provides the first line defense against injury and infection. In …

The endocannabinoid (eCB) signaling system modulates neurotransmission and
inflammation, among other physiological functions. Its newest member, α/β-hydrolase …

In the past two decades, drug candidates with a covalent binding mode have gained the
interest of medicinal chemists, as several covalent anticancer drugs have successfully …

Eicosanoids are cellular metabolites, which shape the immune response, including
inflammatory processes in macrophages. The effects of these lipid mediators on …

Staphylococcus aureus colonizes the nares of approximately 30% of humans, a risk factor
for opportunistic infections. To gain insight into S. aureus virulence potential in the …

Background Cancer-associated bone disease is a serious complication in bone sarcomas
and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is …

Endocannabinoid-metabolizing enzymes are downregulated in response to
lipopolysaccharide (LPS)-induced inflammation in mice, which may serve as a negative …

Background Despite the convergence of rapid technological advances in genomics and the
maturing field of ecoimmunology, our understanding of the genes that regulate immunity in …

Staphylococcus aureus is commonly isolated from astronauts returning from spaceflight.
Previous analysis of omics data from S. aureus low Earth orbit cultures indicated significantly …

The endocannabinoid system (ECS), initially identified for its role in maintaining
homeostasis, particularly in regulating brain function, has evolved into a complex …