A versatile, automated and high-throughput drug screening platform for zebrafish embryos

A Lubin, J Otterstrom, Y Hoade, I Bjedov… - Biology …, 2021 - journals.biologists.com
Zebrafish provide a unique opportunity for drug screening in living animals, with the fast-
developing, transparent embryos allowing for relatively high-throughput, microscopy-based …

The role of TRL7/8 agonists in Cancer Therapy, with special emphasis on hematologic malignancies

M Leśniak, J Lipniarska, P Majka, W Kopyt, M Lejman… - Vaccines, 2023 - mdpi.com
Toll-like receptors (TLR) belong to the pattern recognition receptors (PRR). TLR7 and the
closely correlated TLR8 affiliate with toll-like receptors family, are located in endosomes …

Therapeutic applications of toll-like receptors (TLRs) agonists in AML

Y Peng, Y Wang, M Wang, J Lan, Y Chen - Clinical and Translational …, 2022 - Springer
Acute myeloid leukemia (AML) is an aggressive type of blood cancer affecting bone marrow
(BM). In AML, hematopoietic precursors are arrested in the early stages of development and …

Zebrafish models of inflammation in hematopoietic development and disease

S Ketharnathan, V Rajan, SV Prykhozhij… - Frontiers in Cell and …, 2022 - frontiersin.org
Zebrafish offer an excellent tool for studying the vertebrate hematopoietic system thanks to a
highly conserved and rapidly developing hematopoietic program, genetic amenability …

Nucleic acid-induced inflammation on hematopoietic stem cells

GT Vu, V Awad, MF Norberto, TV Bowman… - Experimental …, 2024 - Elsevier
Highlights•Nucleic acid-sensing inflammatory pathways affect developmental and adult
hematopoiesis.•RNA and DNA sensing pathways are essential for sensing exogenous and …

骨髓增生异常综合征在斑马鱼中的研究进展

易可欣, 范尹尹, 陈柳蓉, 汪玉宝, 朱文武, 贾海波… - 发育医学电子 …, 2024 - fyyxzz.com
骨髓增生异常综合征在斑马鱼中的研究进展 Page 1 《发育医学电子杂志》2024 年1 月第12 卷第
1 期J Dev Med (Electronic Version), Jan. 2024, Vol.12, No.1 ·53· 骨髓增生异常综合征在斑马鱼 …

[HTML][HTML] 骨髓增生异常肿瘤的骨髓微环境促进疾病发生发展的机制

洪明华, 常春康 - Chinese Journal of Hematology, 2023 - ncbi.nlm.nih.gov
骨髓增生异常肿瘤(myelodysplastic neoplasms, MDS) 是一种以造血干细胞克隆增殖,
骨髓增生异常, 无效造血, 外周血细胞减少, 高风险发展为急性髓系白血病(AML) …

[HTML][HTML] Harnessing single-cell technologies in the search for new therapies for Diamond-Blackfan anemia

D Iskander, A Karadimitris, I Roberts - Experimental Hematology, 2024 - Elsevier
The emergence of multi-omic single-cell technologies over the last decade has led to
improved insights into both normal hematopoiesis and its perturbation in a variety of …

Harnessing Single-Cell Technologies in the Search for New Therapies for Diamond–Blackfan Anemia Syndrome

D Iskander, A Karadimitris, I Roberts - Experimental Hematology, 2024 - exphem.org
The emergence of multi-omic single-cell technologies over the last decade has led to
improved insights into both normal hematopoiesis and its perturbation in a variety of …