The division of the cellular space into nucleoplasm and cytoplasm promotes quality control
mechanisms that prevent misprocessed mRNAs and junk RNAs from gaining access to the …

RNA stability and quality control are integral parts of gene expression regulation. A key
factor shaping eukaryotic transcriptomes, mainly via 3′–5′ exoribonucleolytic trimming or …

CK1s are acidophilic serine/threonine kinases with multiple critical cellular functions; their
misregulation contributes to cancer, neurodegenerative diseases, and sleep phase …

The fission yeast Schizosaccharomyces pombe employs two main strategies to adapt to the
environment and survive when starved for nutrients. The strategies employ sporulation via …

Long non-coding RNAs (lncRNAs) contribute to the regulation of gene expression in
response to intra-or extracellular signals but the underlying molecular mechanisms remain …

To eliminate specific or aberrant transcripts, eukaryotes use nuclear RNA-targeting
complexes that deliver them to the exosome for degradation. S. pombe MTREC, and its …

For decades, more and more long non-coding RNAs (lncRNAs) have been confirmed to play
important functions in key biological processes of different organisms. At present, most …

Abstract mRNA biogenesis in the eukaryotic nucleus is a highly complex process. The
numerous RNA processing steps are tightly coordinated to ensure that only fully processed …

Transcriptionally silent chromatin often localizes to the nuclear periphery. However, whether
the nuclear envelope (NE) is a site for post-transcriptional gene repression is not well …

In eukaryotes, the Suv39 family of proteins tri-methylate lysine 9 of histone H3 (H3K9me) to
form constitutive heterochromatin. However, how Suv39 proteins are nucleated at …