Low back pain is the leading cause of disability worldwide and in many patients the source
of pain can be attributed to pathological changes within the intervertebral disc (IVD). As …

As populations age across the world, osteoporosis and osteoporosis-related fractures are
becoming the most prevalent degenerative bone diseases. More than 75 million patients …

Background Nucleus pulposus cell (NPC) death and progressive reduction play important
roles in intervertebral disc degeneration (IVDD). As part of a damage-associated molecular …

The molecular pathophysiology underlying lumbar spondylosis development remains
unclear. To identify genetic factors associated with lumbar spondylosis, we conducted a …

Introduction Low back pain (LBP) is a global health concern. Increasing evidence implicates
intervertebral disk (IVD) degeneration as a major contributor. In this respect, tissue‐specific …

Glycolysis is central to homeostasis of nucleus pulposus (NP) cells in the avascular
intervertebral disc. Since the glucose transporter, GLUT1, is a highly enriched phenotypic …

Bioscaffolds derived from the extracellular matrix (ECM) have shown the capacity to promote
regeneration by providing tissue-specific biological instructive cues that can enhance cell …

Intervertebral disc degeneration is the most significant, and least understood, cause of
chronic back pain, affecting almost one in seven individuals at some point of time. Each …

Degeneration of the nucleus pulposus (NP) might serve as a trigger for intervertebral disc
degeneration (IDD). A recent drug screening study revealed that the thienoindazole …

The intervertebral disc (IVD) is composed of three separate tissues with distinct origins and
properties. Elucidating changes occurring in these tissues in response to injury or age is …