A critical overview of targeted therapies for vestibular schwannoma

R Tamura, M Toda - International journal of molecular sciences, 2022 - mdpi.com
Vestibular schwannoma (VS) is a benign tumor that originates from Schwann cells in the
vestibular component. Surgical treatment for VS has gradually declined over the past few …

Understanding the molecular mechanism of vestibular schwannoma for hearing preservation surgery: Otologists' perspective from bedside to bench

M Hosoya, T Wakabayashi, K Wasano, T Nishiyama… - Diagnostics, 2022 - mdpi.com
Vestibular schwannoma is a clinically benign schwannoma that arises from the
vestibulocochlear nerve that causes sensorineural hearing loss. This tumor is clinically and …

Multicenter, prospective, phase II study of maintenance bevacizumab for children and adults with NF2-related schwannomatosis and progressive vestibular …

SR Plotkin, J Allen, G Dhall, JL Campian… - Neuro …, 2023 - academic.oup.com
Background Prospective data on maintenance therapy with bevacizumab for persons with
NF2-related schwannomatosis (NF2-SWN) is lacking. In this prospective multicenter phase II …

[HTML][HTML] Brazilian Society of Otology task force–Vestibular Schwannoma‒evaluation and treatment

VAR Silva, J Lavinsky, HF Pauna, MF Vianna… - Brazilian journal of …, 2023 - Elsevier
Objective To review the literature on the diagnosis and treatment of vestibular schwannoma.
Methods: Task force members were educated on knowledge synthesis methods, including …

[HTML][HTML] Efficacy and Toxicity of Bevacizumab in Children with NF2-Related Schwannomatosis: A Systematic Review

AL Tops, JE Schopman, RW Koot, H Gelderblom… - Cancers, 2025 - mdpi.com
Abstract Background/Objectives: NF2-related schwannomatosis (NF2) is a tumor
predisposition syndrome that typically presents with bilateral vestibular schwannomas …

[HTML][HTML] Tumors of the nervous system and hearing loss: beyond vestibular schwannomas

C Ruiz-García, L Lassaletta, P López-Larrubia… - Hearing Research, 2024 - Elsevier
Hearing loss is a common side effect of many tumor treatments. However, hearing loss can
also occur as a direct result of certain tumors of the nervous system, the most common of …

Neurofibromatosis in children: actually and perspectives

ML Sur, I Armat, G Sur, DC Pop, G Samasca, I Lupan… - Children, 2022 - mdpi.com
The three types of neurofibromatosis, namely type 1, type 2, and schwannomatosis, are
generally associated with various benign tumors affecting the skin and the nervous system …

Schwannoma gene therapy via adeno-associated viral vector delivery of apoptosis-associated speck-like protein containing CARD (ASC): preclinical efficacy and …

SG Ahmed, CA Maguire, SA Cao… - International Journal of …, 2022 - mdpi.com
Schwannomas are tumors derived from Schwann-lineage cells, cells that protect and
support myelinated nerves in the peripheral nervous system. They are typically slow …

A Consensus Statement on the Administration of Systemic Bevacizumab in Patients with Recurrent Respiratory Papillomatosis

SR Best, JM Bock, NB Fowler, EH Raabe… - The …, 2024 - Wiley Online Library
Objective To provide detailed guidance on the administration of systemic bevacizumab in
patients with recurrent respiratory papillomatosis (RRP) based on a detailed review of the …

Targeted Therapies in the Treatment of Vestibular Schwannomas: Current State and New Horizons

DB Welling - Otolaryngologic Clinics of North America, 2023 - oto.theclinics.com
Vestibular schwannomas (VSs) are tumors of Schwann cell origin which are histologically
benign, but clinically significant as hearing loss, facial weakness paralysis, and …