Drug candidate and toxicity screening processes currently rely on results from early-stage in
vitro cell-based assays expected to faithfully represent essential aspects of in vivo …

Human cells in culture have a limited proliferative capacity. After a period of vigorous
proliferation, the rate of cell division declines and a number of changes occur in the cells …

Human adult stem cells are being evaluated widely for various therapeutic approaches.
Several recent clinical trials have reported their safety, showing them to be highly resistant to …

DNA methylation has been comprehensively profiled in normal and cancer cells, but the
dynamics that form, maintain and reprogram differentially methylated regions remain …

Propagation of clonal regulatory programs contributes to cancer development. It is poorly
understood how epigenetic mechanisms interact with genetic drivers to shape this process …

Stable maintenance of gene regulatory programs is essential for normal function in
multicellular organisms. Epigenetic mechanisms, and DNA methylation in particular, are …

The DNA damage response (DDR) is activated upon DNA damage generation to promote
DNA repair and inhibit cell cycle progression in the presence of a lesion. Cellular …

The neoplastic process may involve a cancer stem cell. This concept has emerged largely
from the careful analysis of tumour biopsy systems from haematological, breast and brain …

Histone monoubiquitylation is implicated in critical regulatory processes. We explored the
roles of histone H2B ubiquitylation in human cells by reducing the expression of …

Telomerase activity is essential for human cancer cells in order to maintain telomeres and
provide unlimited proliferation potential and cellular immortality. However, additional non …