Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

Cellular carbohydrates or glycans are critical mediators of biological function. Their
remarkably diverse structures and varied activities present exciting opportunities for …

Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …

This chapter provides an overview of the biological functions of glycans in three broad
categories: structural roles in, on, and outside cells; energy metabolism, including nutrient …

Mucin-type-O-glycosylation on proteins is integrally involved in human health and disease
and is coordinated by an enzyme family of 20 N-acetylgalactosaminyltransferases (GalNAc …

Background Novel immunotherapies targeting cancer-associated truncated O-glycans Tn
(GalNAcα-Ser/Thr) and STn (Neu5Acα2–6GalNacα-Ser/Thr) are promising strategies for …

Transforming growth factor–β (TGF-β) signaling regulates various aspects of cell growth and
differentiation and is often dysregulated in human cancers. We combined genetic …

O-Glycosylation is an omnipresent modification of the human proteome affecting many
cellular functions, including protein cleavage, protein folding, and cellular signaling …