Recent development of gold (I) and gold (III) complexes as therapeutic agents for cancer diseases

Y Lu, X Ma, X Chang, Z Liang, L Lv, M Shan… - Chemical Society …, 2022 - pubs.rsc.org
Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …

Modulating the chemical reactivity of gold complexes in living systems: from concept to biomedical applications

J Jiang, X Xiong, T Zou - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Over the past few decades, research on the chemistry of gold has progressed
rapidly, encompassing topics like catalysis, supramolecular chemistry, molecular …

Organogold(III) Complexes Display Conditional Photoactivities: Evolving From Photodynamic into Photoactivated Chemotherapy in Response to O2 Consumption for …

Y Luo, B Cao, M Zhong, M Liu, X Xiong… - Angewandte …, 2022 - Wiley Online Library
Photodynamic therapy (PDT) is a spatiotemporally controllable, powerful approach in
combating cancers but suffers from low activity under hypoxia, whereas photoactivated …

Computational studies of Au (I) and Au (III) anticancer metallodrugs: A survey

I Tolbatov, A Marrone, C Coletti, N Re - Molecules, 2021 - mdpi.com
Owing to the growing hardware capabilities and the enhancing efficacy of computational
methodologies, computational chemistry approaches have constantly become more …

Bidipyrrin AuIII Complex as a Helical Charged π-Electronic System

R Sengupta, H Hashimoto, Y Haketa, H Sakai… - Organic …, 2023 - ACS Publications
A series of ion pairs based on a bidipyrrin-AuIII complex that acts as a stable helical π-
electronic cation have been prepared via ion-pair metathesis. The helical cation, which …

Dual-bioorthogonal catalysis by a palladium peptide complex

AM Pérez-López, A Belsom, L Fiedler… - Journal of Medicinal …, 2023 - ACS Publications
Artificial metalloenzymes (ArMs) enrich bioorthogonal chemistry with new-to-nature
reactions while limiting metal deactivation and toxicity. This enables biomedical applications …

Modulations of a Metal–Ligand Interaction and Photophysical Behaviors by Hückel–Möbius Aromatic Switching

J Kim, J Oh, S Park, T Yoneda, A Osuka… - Journal of the …, 2021 - ACS Publications
In organometallic complexes containing π-conjugated macrocyclic chelate ligands,
conformational change significantly affects metal–ligand electronic interactions, hence …

A Conformationally Restricted Gold (III) Complex Elicits Antiproliferative Activity in Cancer Cells

S Gukathasan, OA Obisesan, S Saryazdi… - Inorganic …, 2023 - ACS Publications
Diamine ligands are effective structural scaffolds for tuning the reactivity of transition-metal
complexes for catalytic, materials, and phosphorescent applications and have been …

[(C C)Au(N N)]+ Complexes as a New Family of Anticancer Candidates: Synthesis, Characterization and Exploration of the Antiproliferative Properties

S Khodjoyan, E Remadna, H Dossmann… - … A European Journal, 2021 - Wiley Online Library
A library of eleven cationic gold (III) complexes of the general formula [(CC) Au (NN)]+ when
CC is either biphenyl or 4, 4'‐ditertbutyldiphenyl and NN is a bipyridine, phenanthroline or …

Emerging anticancer therapeutic modalities brought by gold complexes: overview and perspectives

M Salmain, B Bertrand - European Journal of Inorganic …, 2023 - Wiley Online Library
The medicinal chemistry of gold has experienced an exponential development since the
2000s. For long, the mechanisms of action of gold complexes have been limited to direct …