The transcription factor p53 is an important regulator of a multitude of cellular processes. In
the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest …

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Merkel cell carcinoma (MCC) is an uncommon invasive form of skin cancer that typically
manifests as a nodule on the face, head, or neck that is flesh-colored or bluish-red in …

Named as the guardian of the genome, p53 is a tumor suppressor that regulates cell
function, often through many different mechanisms such as DNA repair, apoptosis, cell cycle …

Adrenocortical carcinoma (ACC) is a highly malignant infrequent tumor with a dismal
prognosis. microRNAs (miRNAs, miRs) are crucial in post-transcriptional gene expression …

Autophagy is a highly conserved process that maintains cellular homeostasis during
evolution. Autophagy can occur in the form of macroautophagy, microautophagy or …

Pro-inflammatory stress is inherent in any cells that are subject to damage or threat of
damage. It is defined by a number of universal components, including oxidative stress …

Effective cancer therapies with limited side effects are urgently needed, for which silver
nanoparticles (AgNPs) have shown potential. However, environmentally friendly methods for …

Iron, as an essential trace element for the organism, is vital for maintaining the organism's
health. Excessive iron can promote reactive oxygen species (ROS) accumulation, thus …

Dynamic interactions between organelles are responsible for a variety of intercellular
functions, and the endoplasmic reticulum (ER)–mitochondrial axis is recognized as a …