Modern drug discovery is increasingly in need of a novel paradigm to replace the classical
blockbuster-based economic model of large pharmaceutical companies. Loss of patent …

Animal venoms and toxins are now recognized as major sources of bioactive molecules that
may be tomorrow's new drug leads. Their complexity and their potential as drug sources …

In the four decades since toxinologists in Australia and elsewhere started to investigate the
active constituents of venomous cone snails, a wealth of information has emerged on the …

Due to their complexity and diversity, animal venoms represent an extensive source of
bioactive compounds such as peptides and proteins. Conventional approaches for their …

Using assay-directed fractionation of the venom from the vermivorous cone snail Conus
planorbis, we isolated a new conotoxin, designated pl14a, with potent activity at both …

Bioactive compounds are abundant in animals originating from marine ecosystems. Ion
channels, which include sodium, potassium, calcium, and chloride, together with their …

Phycobilisomes are light-harvesting protein complexes and are widely distributed in red
algae and cyanobacteria. Each phycobilisome contains highly fluorescent protein …

Conopeptides and conotoxins are small peptides produced by cone snails as a part of their
predatory/defense strategies that target key ion channels and receptors in the nervous …

Ion channels are a type of protein channel that play a vital role in numerous physiological
functions by facilitating the passage of ions through cell membranes, thereby enabling ion …

The evolutionarily unique and ecologically diverse family Conidae presents fundamental
opportunities for marine pharmacology research and drug discovery. The focus of this …