Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …

The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …

Wnt/β-catenin signaling is implicated in many physiological processes, including
development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin …

Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

Colorectal cancer (CRC) is one of the most common malignant tumor types occurring in the
digestive system. The incidence of CRC has exhibits yearly increases and the mortality rate …

Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …

Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …

Pancreatic ductal adenocarcinoma (PDA) is associated with activation of WNT signaling.
Whether this signaling pathway regulates the tumor microenvironment has remained …

Porcupine is a constituent of the 19 membered Wnt family with diverse biological features
such as cell differentiation, cell proliferation, cell migration, apoptosis, etc. Porcupine is a …