Regulator of G-protein signaling (RGS) proteins as drug targets: Progress and future potentials

JB O'Brien, JC Wilkinson, DL Roman - Journal of Biological Chemistry, 2019 - ASBMB
G protein–coupled receptors (GPCRs) play critical roles in regulating processes such as
cellular homeostasis, responses to stimuli, and cell signaling. Accordingly, GPCRs have …

Roles for regulator of G protein signaling proteins in synaptic signaling and plasticity

KJ Gerber, KE Squires, JR Hepler - Molecular pharmacology, 2016 - ASPET
The regulator of G protein signaling (RGS) family of proteins serves critical roles in G protein-
coupled receptor (GPCR) and heterotrimeric G protein signal transduction. RGS proteins are …

Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens

PF Marcott, S Gong, P Donthamsetti, SG Grinnell… - Neuron, 2018 - cell.com
Dopamine input to the dorsal and ventral striatum originates from separate populations of
midbrain neurons. Despite differences in afferent inputs and behavioral output, little is …

Control of striatal signaling by g protein regulators

K Xie, KA Martemyanov - Frontiers in neuroanatomy, 2011 - frontiersin.org
Signaling via heterotrimeric G proteins plays a crucial role in modulating the responses of
striatal neurons that ultimately shape core behaviors mediated by the basal ganglia circuitry …

Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain*♦

C Orlandi, K Xie, I Masuho, A Fajardo-Serrano… - Journal of Biological …, 2015 - ASBMB
Regulators of G protein signaling control the duration and extent of signaling via G protein-
coupled receptor (GPCR) pathways by accelerating the GTP hydrolysis on G protein α …

Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells

I Masuho, K Xie, KA Martemyanov - Journal of Biological Chemistry, 2013 - ASBMB
Regulator of G protein signaling (RGS) proteins play essential roles in the regulation of
signaling via G protein-coupled receptors (GPCRs). With hundreds of GPCRs and dozens of …

Association of Rgs7/Gβ5 complexes with girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons

A Fajardo‐Serrano, N Wydeven, D Young… - …, 2013 - Wiley Online Library
In the hippocampus, signaling through G protein‐coupled receptors is modulated by
Regulators of G protein signaling (Rgs) proteins, which act to stimulate the rate of GTP …

Regulators of G protein signaling in analgesia and addiction

F Sakloth, C Polizu, F Bertherat, V Zachariou - Molecular Pharmacology, 2020 - ASPET
Regulator of G protein signaling (RGS) proteins are multifunctional proteins expressed in
peripheral and neuronal cells, playing critical roles in development, physiologic processes …

R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine

GR Anderson, Y Cao, S Davidson, HV Truong… - …, 2010 - nature.com
In the striatum, signaling through G protein-coupled dopamine receptors mediates motor
and reward behavior, and underlies the effects of addictive drugs. The extent of receptor …

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex

DN Patil, ES Rangarajan, SJ Novick, BD Pascal… - Elife, 2018 - elifesciences.org
Signaling by the G-protein-coupled receptors (GPCRs) plays fundamental role in a vast
number of essential physiological functions. Precise control of GPCR signaling requires …