Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent
advances in biological technologies have been advancing the delineation of genetic …

Medullary thyroid carcinoma (MTC) is a rare type of tumor that originates from thyroid C cells
and accounts for 2–4% of all malignant thyroid neoplasms. MTC may occur sporadically or …

Purpose: Positive results of phase I studies evaluating lenvatinib in solid tumors, including
thyroid cancer, prompted a phase II trial in advanced medullary thyroid carcinoma (MTC) …

Medullary thyroid carcinoma (MTC) is a rare malignancy originating from the calcitonin-
secreting parafollicular thyroid C cells. Approximately 75% of cases are sporadic …

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis.
Defects in this pathway in human cancer syndromes such as Cowden's disease and Multiple …

Background This phase II study investigated the efficacy and safety of everolimus, an
inhibitor of mammalian target of rapamycin (mTOR), in locally advanced or metastatic thyroid …

MicroRNAs are a primordial mechanism of gene expression control that appear to be crucial
to cellular development and may play an important role in tumor development. Much is …

Medullary thyroid carcinoma (MTC) is a neuroendocrine malignant tumor originating from
parafollicular C-cells producing calcitonin. Most of cases (75%) are sporadic while the …

Timely and accurate maps of fine-grained urban villages (UVs) are essential for rational
urban planning, which highlights the importance for automatic recognition methods as …

Our understanding of the genomics and epigenomics of medullary thyroid carcinoma (MTC)
has advanced since the initial recognition of RET as a driver of MTC tumorigenesis in …